The compounds were tested in multiple rounds of synthesis and biologically evaluated to determine and better develop their biofilm-eradication potential. UF researchers chemically synthesized 39 HQ compounds with different chemical groups and properties at the 2-position. “In this study, we wanted to develop compounds that have a high degree of structural diversity at the 2-position and evaluate their biofilm-eradication activities.” “We do not yet know why the 2-position of the HQ scaffold is so important, but it is clear that it dramatically influences antibacterial activities,” Huigens said. Huigens’ team discovered that small changes at a location called the 2-position on the quinoline structure can dramatically impact the potency and ability of HQ compounds to destroy bacterial biofilms. The representations include a core group of atoms and numbered positions that can be manipulated to develop and test new compounds. “Our goal is to develop HQ small molecules, so that they can help patients affected by biofilm-associated bacterial infections.”Ĭhemists synthesize structural representations of molecular frameworks as models to study different chemical groups at different positions in a compound. “When you can control the biological activity and properties of a molecule, you have greater potential of developing a drug,” said Rob Huigens, Ph.D., an assistant professor of medicinal chemistry and lead investigator of a study about HQ compounds published in Chemistry – A European Journal. In addition, researchers identified a way for chemists to better control the structural elements of HQ compounds which improves the likelihood of developing them into biofilm-attacking drug molecules.
#Dodge durango forum. series#
UF scientists recently discovered that a series of organic compounds called halogenated quinolines, or HQs, can kill dangerous bacterial biofilms present in recurring and chronic bacterial infections such as methicillin-resistant Staphylococcus aureus, or MRSA. The biofilm-growing cells are largely resistant to conventional antibiotic treatments and can linger for months or even years. Just as a piano tuner adjusts the tension of the strings for optimal sound, medicinal chemists at the University of Florida College of Pharmacy are fine-tuning the structural positions of chemical compounds to find the most promising drug options for killing dangerous bacterial biofilms.Īn estimated 17 million Americans are affected by biofilm-associated bacterial infections annually. Pictured l to r, Yasmeen Abouelhassan, Akash Basak, Dr. Medicinal chemists at the University of Florida recently discovered a series of organic compounds that can kill dangerous bacterial biofilms. Undergraduate Research: University Research Scholars Program Pharmacotherapy and Translational ResearchĬenter for Integrative Cardiovascular and Metabolic DiseaseĬenter for Natural Products, Drug Discovery and Development (CNPD3)Ĭenter for Pharmacogenomics and Precision MedicineĬenter for Pharmacometrics and Systems Pharmacology
#Dodge durango forum. professional#
Find out more about our advertising opportunities.Office of Faculty Affairs and Professional Development Advertise Advertising on is well-targeted, has unique benefits, and is highly successful. Looking for something lighter? Read our funny complaints to see people who found humor in a bad situation. Vehicle Problems Find out what cars to avoid, view the latest problem trends, or keep up-to-date with the most recently reported problems. Contact us with any comments or concerns.
#Dodge durango forum. drivers#
Car Problem Resources Around the Site Information Find out more about us in the press or read stories from drivers who praise our work.The complaints are organized into groups with data published by vehicle, vehicle component, and specific problem. ® is an online automotive complaint resource that uses graphs to show automotive defect patterns, based on complaint data submitted by visitors to the site.